Response to: Kim et al., “Axon Regeneration in Young Adult Mice Lacking Nogo-A/B.” Neuron 38, 187–199

نویسندگان

  • Oswald Steward
  • Binhai Zheng
  • Karla Banos
  • Kelly Matsudaira Yee
چکیده

Oswald Steward,* Binhai Zheng, Karla Banos, and Kelly Matsudaira Yee Departments of Anatomy & Neurobiology and Neurobiology & Behavior, Reeve-Irvine Research Center, University of California at Irvine College of Medicine, Irvine, CA 92697-4292, USA Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA *Correspondence: [email protected] DOI 10.1016/j.neuron.2007.04.004

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منابع مشابه

Response to Correspondence: Kim et al., “Axon Regeneration in Young Adult Mice Lacking Nogo-A/B.” Neuron 38, 187–199

Experimental Procedures Experimental Animals Our repeat of the study by Kim et al. (2003) used 8to 10-week-old Nogo knockout mice (the gene trap mutant that was generously provided by these authors) and littermate controls obtained by backcrossing homozygous knockout mice to C57BL/6 mice. Young adult (8to 10-week-old) female mice of the C57BL/6 strain were used in the experiment that involved d...

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Axon Regeneration in Young Adult Mice Lacking Nogo-A/B

After injury, axons of the adult mammalian brain and spinal cord exhibit little regeneration. It has been suggested that axon growth inhibitors, such as myelin-derived Nogo, prevent CNS axon repair. To investigate this hypothesis, we analyzed mice with a nogo mutation that eliminates Nogo-A/B expression. These mice are viable and exhibit normal locomotion. Corticospinal tract tracing reveals no...

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Nogo-66 Receptor Prevents Raphespinal and Rubrospinal Axon Regeneration and Limits Functional Recovery from Spinal Cord Injury

Axon regeneration after injury to the adult mammalian CNS is limited in part by three inhibitory proteins in CNS myelin: Nogo-A, MAG, and OMgp. All three of these proteins bind to a Nogo-66 receptor (NgR) to inhibit axonal outgrowth in vitro. To explore the necessity of NgR for responses to myelin inhibitors and for restriction of axonal growth in the adult CNS, we generated ngr(-/-) mice. Mice...

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Lack of Enhanced Spinal Regeneration in Nogo-Deficient Mice

The failure of regeneration of severed axons in the adult mammalian central nervous system is thought to be due partly to the presence of endogenous inhibitors of axon regeneration. The nogo gene encodes three proteins (Nogo-A, -B, and -C) that have been proposed to contribute to this inhibition. To determine whether deletion of nogo enhances regenerative ability, we generated two lines of muta...

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Using Gene Knockout and Transgenic Approaches to Evaluate in vivo Functions of CNS Regeneration Inhibitors: How Important is Nogo?

Nerve cells of the central nervous system (CNS) are distinct from the peripheral nervous system (PNS) in that they are not capable of regenerating after injury (Purves, D. et al. 2001). In recent studies, scientists have discovered that the agents causing this inability to regenerate are myelin-derived protein inhibitors that form three families—MAG, OMgp, and Nogo with a common receptor, NgR (...

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عنوان ژورنال:
  • Neuron

دوره 54  شماره 

صفحات  -

تاریخ انتشار 2007